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Factors affecting survival following radical mastectomy
Author(s) -
Freund H.,
Grover N. B.,
Durst A. L.
Publication year - 1978
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930100303
Subject(s) - medicine , breast cancer , mastectomy , radical mastectomy , pathological , stage (stratigraphy) , lymph node , survival analysis , prospective cohort study , oncology , modified radical mastectomy , surgery , cancer , paleontology , biology
Data on 17 potentially useful factors from 152 women undergoing radical mastectomy for operable breast cancer were analyzed in order to determine the effect of each on survival and their relative importance. Only four, clinical stage, clinical and pathological lymph node involvement, and appearance of recurrence and metastases, proved to be of significant prognostic value. Axillary nodal involvement was the main single determinant of survival. Multiple regression analysis, based on factor analysis of the original input variables, was able to account for 34% of the variance in survival and is thus of only very limited use as a predictive instrument in the clinical management of prospective patients.