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Effect of surgery on granulocyte/macrophage colony‐stimulating factor
Author(s) -
Reines Howard D.,
Foster Roger S.
Publication year - 1978
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930100208
Subject(s) - medicine , granulocyte , granulocyte macrophage colony stimulating factor , bone marrow , urinary system , urine , colony stimulating factor , excretion , granulocyte colony stimulating factor , toxicity , immunology , endocrinology , haematopoiesis , chemotherapy , cytokine , biology , stem cell , genetics
Eighteen surgical patients were studied to determine the effect of anesthesia (general or spinal) and surgery on serum and urinary colony‐stimulating factor(s) (CSF). CSF is a leukopoietin that stimulates proliferation of macrophages and granulocytes from bone marrow precursor cells. CSF was assayed by adding aliquots of serum or urine to semisolid agar cultures of bone marrow cells and scoring the number of colonies developing after 7 days of incubation. In all but 1 case, a 3‐ to 30‐fold increase in the 24 hour excretion of urinary CSF was seen on the day of surgery and the first postoperative day. CSF urinary excretion began declining toward normal by the second postoperative day. A parallel increase in granulocyte count, a delayed rise in monocytes, and a decline in absolute lymphocyte counts were also observed. The data suggest that immediately postoperatively there may be a strong stimulus to granulocyte/macrophage proliferation. More rapidly proliferating cells would be anticipated to have increased vulnerability to toxicity from cell cycle‐active chemotherapeutic agents.