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Effects of the combination of tumor‐specific and nonspecific immunization on tumor suppression
Author(s) -
Mori Tsuneatsu,
Sekiguchi Morimasa,
Fujii Genshichiro,
Inou Tsunamasa,
Kitamura Masaru
Publication year - 1977
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930090407
Subject(s) - immunogenicity , adjuvant , medicine , tumor cells , immunization , mycobacterium tuberculosis , cancer research , tuberculosis , immunology , pathology , immune system
The crushed whole Aoyama B cells attached to oil droplets were found to be most suitable for the adjuvant effect of Mycobacterium tuberculosis against tumor growth when judged by the criterion of effectiveness and a clinical application with minimal side effects. The immunogenicity of tumor cells was well stabilized and maintained with a suitable concentration of formalin; this was less than 1% and the optimum concentration was 0.05% or 0.1%. When the tumor cells treated with the optimum concentration of formalin were combined with suitable adjuvant, immunoprotection against the tumor progress was accelerated.