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Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age
Author(s) -
Goldrosen Martin H.,
Han Tin,
Jung Okhee,
Smolev James,
Holyoke E. Douglas
Publication year - 1977
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930090304
Subject(s) - immunocompetence , medicine , lymphocyte , adenocarcinoma , disease , cellular immunity , immunology , immune system , cancer
The in vitro blastogenic response of 76 patients with colon adenocarcinoma and 29 age‐matched normal healthy volunteers was compared. An age‐related decline in cellular immunocompetence was observed in both the patient and control group. Within each age interval, the patients' blastogenic responses were lower than the controls' and the rate of decline of the blastogenic response in the patient group was greater in magnitude, suggesting that their disease state also contributed to loss of cellular immunocompetence. Thus, both increasing age and presence of tumor are factors that contribute to the decline in immunocompetence in patients with colon adenocarcinoma.