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Active immunization against spontaneous tumors in mice
Author(s) -
Patrício M. B.,
Clode W. H.,
Ricardo J. A.
Publication year - 1977
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930090203
Subject(s) - ovary , medicine , lung , mammary gland , immunization , pathology , mammary tumor , incidence (geometry) , cancer , immunology , antibody , breast cancer , physics , optics
The incidence of spontaneous tumors was studied in a group of 136 female mice and in another group of 138 females after a sublethal dose of total body irradiation. Of the nonirradiated mice 10.2% developed mammary tumors, and 8% developed lung tumors. Of the irradiated mice 19.5% developed mammary tumors, 21.7% ovary tumors, 24.5% lung tumors, and 7.9% tumors in other organs. A vaccine was prepared for only mammary and ovary tumors through an original technique. The results showed a significantly lower incidence of tumors in another two groups of mice that were immunized: in 80 nonirradiated vaccinated female mice, mammary tumors decreased from 10.2% to 2.5%, and in 78 irradiated and vaccinated female mice, mammary tumors decreased from 19.5% to 8.9% and ovary tumors from 21.7% to 3.8%. Lung tumors also decreased in the latter group, suggesting a common factor protecting the immunized mice.