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Responsiveness to endocrine manipulations in breast cancer after “prophylactic” castration
Author(s) -
Kaufman Richard,
Salem Philip,
Wittes Robert E.
Publication year - 1977
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930090107
Subject(s) - medicine , castration , endocrine system , breast cancer , cancer , endocrine disease , oncology , disease , physiology , gynecology , hormone
Two hundred and one cases of premenopausal women with breast cancer who underwent prophylactic castration with subsequent recurrence were reviewed to ascertain the degree of responsiveness of these patients to subsequent endocrine manipulation. We show that the standard endocrine manipulations, particularly the major ablations, retain a fair degree of activity in this group. There is a suggestion that the longer the castration‐recurrence interval, the higher the chance of a response, but the difference is significant only for osseous‐dominant disease. As in other patient groups, responders to subsequent endocrine manipulations live longer than nonresponders.