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Serum ribonuclease in patients with lung carcinoma
Author(s) -
Marabella Patrick C.,
Tritsch George L.,
Moore Robert H.,
Takita Hiroshi
Publication year - 1976
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930080609
Subject(s) - rnase p , ribonuclease , lung , medicine , cellular immunity , immunity , carcinoma , pathology , cancer research , immunology , immune system , biology , rna , biochemistry , gene
Fifty‐one previously untreated cases of lung carcinoma and 7 normal healthy controls were evaluated with respect to serum ribonuclease (S‐RNase) levels. Cellular immunity was tested in 22 of these 51 cases by leukocyte migration inhibition test (MIT) using extract of culture cell line of lung carcinoma. S‐RNase levels in lung carcinomas were significantly elevated. There appeared to be no difference in S‐RNase levels by histological classification. More striking was high S‐RNase level in disseminated versus localized cases. MIT results indicated impairment of cellular immunity in those cases of more elevated S‐RNase. S‐RNase may be implicated in blocking phenomenon associated with neoplastic disease.