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Cell‐mediated immune response in head and neck cancer patients
Author(s) -
Olivari A.,
Pradier R.,
Feierstein J.,
Guardo A.,
Glait H.,
Rojas A.
Publication year - 1976
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930080405
Subject(s) - medicine , immune system , head and neck cancer , head and neck , population , malignant transformation , cancer , lymphocyte , radiation therapy , oncology , immunology , pathology , surgery , environmental health
The immune reactivity of 100 head and neck cancer patients was studied by means of DNCB, candidine, blastic transformation with PHA, and lymphocyte counts. DNCB reactivity was strong in only 21% of the population and was found impaired in patients with advanced primitive tumors, with more than one primitive tumor, and in patients after radiation. Candidine reactivity was impaired in bigger primitive tumors, positive nodes, and advanced stages, as well as in postradiation patients. Blastic transformation was significantly worse in patients over 70 years and tended to be lower in patients with more than one primitive tumor. Good blastic transformation was also lowered in postradiation patients.