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Erythropoietin levels in wistar‐furth Wilms' tumor rats
Author(s) -
Murphy Gerald P.,
Williams Phyllis D.,
Mirand Edwin A.
Publication year - 1976
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930080207
Subject(s) - medicine , erythropoietin , wilms' tumor , lymphatic system , hormone , anemia , endocrinology , animal model , pathology
Erythropoietin (ESF) levels were assayed in rats bearing the Wistar‐Furth Wilms' transplantable tumor. Sites of tumor inoculation varied from subcutaneous, intramuscular, intrarenal (subcapsular), to intra‐peritoneal. Two‐thirds of the animals exhibited ESF elevations without polycythemia, or severe anemia (HCT < 30.0 vol %). The elevations in ESF were not detectably related to the time of sacrifice (age of the animal), size of the primary tumor, or number of gross metastatic foci. The diminished ESF response noted to animals given intramuscular tumor implantations is believed to reflect differences in tumor blood and lymphatic supply at the various sites of inoculation. The pattern of ESF responses in the Wistar‐Furth Wilms' tumor model is thus quite similar to that which we have observed in man, and appears to represent an animal model for tumor‐related ectopic hormone release. The nature of the hormone is believed to differ from that seen in normal physiological states.