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Medullary thyroid carcinoma
Author(s) -
Raynor A. Clark,
Sowden David
Publication year - 1975
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930070602
Subject(s) - medicine , medullary cavity , thyroid carcinoma , medullary carcinoma , thyroid , carcinoma , pathology , oncology , general surgery
Medullary thyroid carcinoma is an infrequent and unusual malignancy. Since its description 15 years ago, many new features have developed. Many biologically active compounds which are directly related to the different symptoms of the disease have been recovered from the tumors. A familial incidence is noted, and there is an increased association with other tumors and their behavior. The cell of origin is the parafollicular cell, which secretes calcitonin and is responsible for the unusual behavior of medullary thyroid carcinoma. Treatment is primarily surgical. Four cases are presented and the syndrome reviewed.