Premium
Inhibition of melanoma growth in hamsters by type‐2 adenovirus
Author(s) -
Khoobyarian Newton,
Barone Frank,
Sabet Tawfik,
ElDomeiri Ali A.,
Gupta Tapas K. Das
Publication year - 1975
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930070514
Subject(s) - hamster , medicine , virus , melanoma , virology , tumor cells , immunity , pharmacology , immunology , cancer research , immune system
Abstract Type‐2 adenovirus was shown to inhibit the growth of transplantable hamster melanoma in 70% of Syrian hamsters without any injurious effect to the host. Greatest inhibition of tumor formation was seen when animals were injected with 10 6 TCD 50 of adenovirus and 2.5 × 10 5 tumor cells, or 10 6 TCD 50 of virus and 5.0 × 10 5 tumor cells followed either 1 or 7 days later by a second injection of a similar dose of virus. Significant inhibition in tumor growth was also noted when 2 injections of virus (10 6.2 TCD 50 /injection) were given on 2 separate occasions as late as 7 and 10 days after the inoculation of tumor cells. The mechanism of tumor inhibition is not known but it could be due to a combination of factors such as viral toxicity, viral oncolysis, and antitumor immunity.