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Offsetting toxicity of antineoplastic agents
Author(s) -
Cook Elton S.,
Nutini Leo G.,
Fardon John C.,
Bernadette Proudfoot M. Agnes,
Poydock M. Eymard
Publication year - 1975
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930070503
Subject(s) - methotrexate , medicine , ascites , in vivo , toxicity , pharmacology , fluorouracil , leukemia , in vitro , antimetabolite , chemotherapy , bone marrow , cancer research , biochemistry , biology , microbiology and biotechnology
PCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions. In vivo, PCO enhances the action of methotrexate against the L‐1210 lymphoid leukemia and does not interfere with the effectiveness of fluorouracil against the ascites Krebs‐2 tumor.