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Glycogen metabolism in epidermal wound healing
Author(s) -
Hoopes John E.,
Im Michael J. C.
Publication year - 1974
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930060505
Subject(s) - glycogen , epithelium , wound healing , ischemia , glycogen synthase , medicine , endocrinology , pathology , surgery
Enzymatic cycling methods have been applied to the quantitative measurement of glycogen content during wound healing and utilized for an estimation of the contribution of glycogen to metabolism in association with ischemia. Tissue glycogen accumulated in regenerating epithelium during the fnst 7 days of wound healing. Increasing gradients of glycogen concentration were demonstrated from the marginal epithelium to the distal portions of the migrating epithelium. Glycogen content was increased to 13 times normal in the distal portion of migrating epithelium on day 3 post‐injury. A study of ischemia revealed that the accumulated glycogen appeared to constitute an emergency ration for repairing epithelium and contributed considerably to energy production.