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Preferential splenic metastases in parabiotic animals
Author(s) -
Schour Lionel,
Faraci Robert P.
Publication year - 1974
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930060204
Subject(s) - parabiosis , spleen , medicine , neoplasm , pathology , immunity , immunology , immune system
A reticulum cell sarconia which metastasizes preferentially to the spleens of inbred C 3 H mice has been studied. Placement of tumor‐bearing animals in parabiosis with normal animals was followed by the development of gross metastases limited to the spleen in 100% of the normal animals. The pattern of metastases observed when a tumor‐bearing animal was placed in parabiosis with a splenectomized animal is described. The splenotrophic tendencies of this tumor and its ability to metastasize selectively across a parabiotic union provide a model for investigation of the role of immunity and humoral factors in tumor metastases.