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The effect of a yeast extract (PCO) on the mitotic activity of neoplastic and normal cells in vitro
Author(s) -
Fardon John C.,
Poydock Sister M. Eymard,
Tsuchiya Yoshiki
Publication year - 1973
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930050406
Subject(s) - in vitro , mitosis , yeast , ehrlich ascites carcinoma , medicine , pathology , cancer research , biochemistry , biology , microbiology and biotechnology
An aqueous‐alcoholic extract of yeast (PCO) was found to inhibit mitoses in Sarcoma 180, Krebs‐2 ascites carcinoma, and the L–1210 leukemia in vitro. Contrariwise, PCO did not inhibit, and in some experiments even stimulated, the mitoses in the following normal cells in vitro: L‐929 fibroblasts; two established lines of mouse corneal cells; and mouse bone marrow cells.