Premium
Erythropoietic response of the neonatal rat to hypertransfusion and erythropoietin (Ep)
Author(s) -
Cantor Linda N.,
Gordon Albert S.
Publication year - 1973
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930050203
Subject(s) - erythropoiesis , medicine , erythropoietin , stimulation , endocrinology , anemia
A sustained state of plethora cannot be induced in neonatal rats by intraperitoneal injections of RBC. On the other hand, erythropoiesis is markedly and rapidly suppressed by intra‐cardiac injections of RBC. The data suggest that administration of Ep to such animals results in a two‐fold action: an early release of reticulocytes followed by a true stimulation of erythropoiesis.