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5‐methyl‐cytidine as an inhibitor of spontaneous cancer in mice
Author(s) -
Strong Leonell C.,
Matsunaga Henry
Publication year - 1972
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930040515
Subject(s) - cytidine , inhibitory postsynaptic potential , proband , medicine , cancer , mechanism of action , cancer research , endocrinology , pharmacology , biochemistry , biology , enzyme , in vitro , gene , mutation
Three nucleosides, found in a specially prepared liver emulsion (Mittelman), are inhibitors of the growth of spontaneous tumors of mammary gland origin in mice. The present data demonstrate that 5 methyl cytidine when used in the same molar concentration (0.02) as it is found in the liver emulsion is a powerful inhibitor of spontaneous adenocarcinomata irrespective of age of the cancer proband. More inhibition is obtained in mice between 9 and 12 months of age than between 5 and 8 months. The later appearing tumors (at 9–12 months) grow faster in the controls than those which develop between 5 and 8 months of age. It is reasonable to conclude that 5 methly cytidine has a more inhibitory action on fast growing tumors than upon slower growing ones. However, this inhibitory difference may be mediated somehow or other by a “transmissible entity” or by some other secondary mechanism associated with the aging process. The present series of experiments suggests the possibility that by the simultaneous or tandem use of several nucleosides a broader effect of an inhibitory action on cancer in mice may be forthcoming.