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Continuous intravenous fucose treatment of rat mammary tumor
Author(s) -
Rosato F. E.,
Mullen J. L.,
Rosato E. F.,
Steiger E.,
Miller E.
Publication year - 1972
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930040204
Subject(s) - fucose , medicine , spleen , catheter , surgery , toxicity , kidney , diuresis , endocrinology , glycoprotein , biology , microbiology and biotechnology
Thirteen male, adult, 400‐gm Lewis‐Wistar rats received implants of a transplantable mammary tumor, which had arisen spontaneously in rats being treated with N‐N Dimethyl B‐Aziridino propionamide. Three rats (controls) received no treatment, five were given dextrose (8.7 mg/kg/day) and five given L‐fucose (7.6 mg/kg/day) for four days. The sugars were adminstered by continuous intravenous infusion through a catheter placed in the superior vena cava which was maintained in position with a swivel harness apparatus allowing complete freedom of motion during therapy. There was a 20% reduction in tumor size (mean diameter) during fucose infusion, while the controls increased by 5%. The fucose did produce a diuresis but no toxicity was encountered. At sacrifice, on the 23rd day of tumor growth, bone marrow, liver, kidney, and spleen were normal histologically. Tumor fucose was approximately doubled in those receiving fucose, as compared to the control and dextrose treated animals.