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Morphology of thymic grafts exposed to lymphomagenic virus
Author(s) -
Hays Esther F.
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030506
Subject(s) - virus , pathology , lymphoma , renal capsule , reticular cell , cortex (anatomy) , regeneration (biology) , lymphoblast , biology , medicine , kidney , spleen , anatomy , virology , immunology , cell culture , microbiology and biotechnology , endocrinology , genetics , neuroscience
Syngeneic thymic grafts in AKR mice were exposed in vitro to lymphomagenic virus, grafted subcutaneously or under the kidney capsule, and biopsied at intervals. No specific morphologic change was seen to precede the development of lymphoma in these grafts. Lymphoma was found to develop initially as foci of lymphoblasts in the cortex of a normal‐appearing thymus. Regeneration of syngeneic virus‐exposed thymic epithelial remnant grafts in AKR mice was compared to that of nonvirus‐exposed grafts in the same strain and to that in a low‐incidence lymphoma strain. All of the grafts were found to regenerate to the morphology of normal thymus with a characteristic sequence of cellular events. These results imply that lymphomagenic virus acts by a direct transformation of cells in the thymic cortex which is not dependent on any preceding structural alteration of this organ and that regeneration of grafts composed of epithelial reticular cells was not impaired or altered by the presence of the virus.