Premium
The stimulation and inhibition of the growth capacities of spontaneous tumors of mammary gland origin in mice (adenocarcinomata)
Author(s) -
Strong Leonell C.,
Matsunaga Henry
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030412
Subject(s) - stimulation , incubation , medicine , growth inhibition , moiety , mammary gland , endocrinology , cancer research , cancer , biochemistry , biology , cell growth , chemistry , stereochemistry , breast cancer
Abstract Following incubation at 40 C for 10 days, a liver emulsion was divided into two moieties. One (REF) was aged in the refrigerator; the other (ART) was aged at room temperature. With each moiety there were obtained three reactions in regard to the growth capacity of spontaneous tumors. These observations were in sequence (1) a stimulation of growth rate of tumors, (2) no effect on growth capacity of tumors, and finally (3) a pronounced inhibition of tumor growth. Since three of the entities contained in the liver emulsion have been determined by Dr. Arnold Mittleman of Roswell Park Memorial Institute, Buffalo, New York, a brief discussion of these facts is included. These observations emphasize very significantly the role of temperature control and aging of the tumor inhibitor in the development of cancer suppression in spontaneous neoplasms in mice.