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Adenocarcinoma and transitional cell carcinoma occurring simultaneously in the urinary bladder (mixed tumor)
Author(s) -
Fegen J. Peter,
Albert David J.,
Persky Lester
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030404
Subject(s) - medicine , adenocarcinoma , malignancy , transitional cell carcinoma , urinary bladder , neck of urinary bladder , transitional cell , carcinoma , transitional epithelium , mixed tumor , urology , pathology , oncology , cancer , bladder cancer
Only five tumors of the urinary bladder containing both adenocarcinoma and transitional cell carcinoma have previously been reported. In spite of this apparent rarity, three patients have been treated at the University Hospitals of Cleveland in the past 2 years with this ‘mixed’ malignancy. Abbreviated case histories, treatment, and follow‐up are discussed. Two of the three patients are alive without evidence of tumor following treatment. The origin of adenocarcinoma appearing as a primary bladder neoplasm may be from a urachal rest, from glandular cells around the bladder neck, from malignant degeneration of cystitis cystica and cystitis glandularis, or from a primary change of transitional epithelium to glandular cancer. The mixed tumor may represent dual malignant degeneration of a common cell line or two primary cancers appearing coincidentally at one time. The prognosis is poor, although the rarity of cases and short follow‐up make efficacy of treatment difficult to evaluate.