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Counteraction of leukopenia caused by mechlorethamine and azathioprine
Author(s) -
Cook Elton S.,
Nutini Leo G.
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030206
Subject(s) - leukopenia , toxicity , medicine , azathioprine , bone marrow , adjuvant , leukocyte counts , pharmacology , gastroenterology , disease
PCO, a deproteinized yeast extract of low toxicity, increases tissue respiration, offsets the toxicity of mechlorethamine hydrochloride (HN2) for mice with maintenance of antineoplastic activity in the systems studied, and is a useful adjuvant to azathioprine in dog renal allografts. The two latter effects appear to be related to the ability of PCO to protect against the leukopenia caused by these drugs. PCO increases the leukocyte count and offsets the leukocyte depression caused by HN2 in mice and rabbits, and protects against bone marrow damage due to HN2 (investigated only in mice). In dogs, PCO lowers the proportion of lymphocytes without significant effect on the total leukocyte count.