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The effect of L ‐fucose on rat mammary tumor growth. I. In vivo studies
Author(s) -
Wolfe Daniel,
Roseman James M.,
Miller Elizabeth,
Seltzer Murray H.,
Rosato Francis E.
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030113
Subject(s) - mammary tumor , in vivo , fucose , medicine , saline , endocrinology , mammary gland , andrology , cancer , biology , breast cancer , microbiology and biotechnology , glycoprotein
Thirty female Lewis‐Wistar rats, each 150–200 g, received equal amounts of chemically induced transplantable mammary tumor. Fifteen of the rats received a daily intraperitoneal injection of 600 mg L‐fucose, while the remaining 15, serving as controls, received saline. The injections were begun the day of tumor implantation and continued for a total of 10 days. All animals were sacrificed on the fifteenth day, Tumor growth, as determined by mean diameter, was significantly suppressed in the experimental group. Serum and tumor levels of fucose were increased in the treated animals as compared to the control animals. These findings suggest retention of fucose, which may play a role in the inhibition of growth of this mammary tumor.