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Respiratory failure in acute pancreatitis. I. The biophysical characteristics of lungs in experimental pancreatitis
Author(s) -
Bolooki Hooshang,
Minkowitz Stanley,
Giammona Samuel T.,
Jude James R.
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030108
Subject(s) - medicine , acute pancreatitis , pancreatitis , hypoxemia , respiratory system , respiratory failure , complication , anesthesia , cardiology
Four percent of patients with acute pancreatitis develop an acute form of respiratory overwork and die within 24 hr. To elucidate the basic physiology of this respiratory failure in a group of dogs after production of acute pancreatitis, the respiratory functions and mechanics were studied and were compared with dogs undergoing sham operation. The results showed diminished pulmonary tissue recoil accompanied by deficiency in gas exchange after acute pancreatitis. The minute respiratory volume and oxygen uptake were increased in the presence of a large pulmonary venoarterial shunt. This was associated with hypoxemia and carbon dioxide retention which could be corrected with respiratory assistance by using a volume‐controlled respirator. In clinical states any evidence of respiratory overwork and decreased P o 2 should be considered as a warning sign of this malignant complication of acute pancreatitis.