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Urinary pseudouridine excretion following hypophysectomy for prostatic carcinoma in man
Author(s) -
Schoonees Rikus,
Mittelman Arnold,
Chheda Girish B.,
Murphy Gerald P.
Publication year - 1971
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930030107
Subject(s) - pseudouridine , hypophysectomy , medicine , excretion , urinary system , endocrinology , urology , cortisone , rna , hormone , biology , biochemistry , gene , uridine
Urinary pseudouridine excretion, which may be used as a good index of RNA turnover in the body, was measured in 25 patients who underwent hypophysectomy for advanced prostatic carcinoma. The excretion of pseudouridine was markedly elevated during the first 4 postoperative days in 9 patients who underwent open surgical hypophysectomy, but it remained essentially unchanged after stereotactic cryohypo‐physectomy in 16 patients. No correlation existed between the urinary pseudouridine excretion and the degree of ablation of pituitary function or the duration of the symptomatic remission of the disease. The body turnover of RNA was apparently not affected by gross ablation of pituitary function (plus cortisone replacement) but was moderately increased by the trauma associated with an open surgical hypophysectomy.