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Acquired Pelger‐Huet anomaly in erythroleukemia
Author(s) -
Phillips Bruce A.,
Yarbro John W.,
Konior Geraldine S.
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020414
Subject(s) - anomaly (physics) , medicine , pathogenesis , pathology , morphology (biology) , biology , genetics , physics , condensed matter physics
The Pelger‐Huet anomaly was found in association with erythroleukemia in a 62‐year‐old female who was known to have had normal granulocyte morphology 9 months previously. This is the third reported case of the coexistence of Pelger‐Huet anomaly with erythroleukemia and the first case in which normal morphology was known to have been present prior to the development of erythroleukemia. Although the pseudo‐Pelger‐Huet anomaly has been reported in association with numerous neoplastic and non‐neoplastic hematologic diseases, its pathogenesis and the clinical significance of its presence remain to be elucidated.