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A ‘transmissible entity’ in the control of cancer in mice
Author(s) -
Strong Leonell C.,
Matsunaga Henry
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020408
Subject(s) - cancer , section (typography) , medicine , potency , mammary gland , cancer research , biology , oncology , genetics , breast cancer , in vitro , computer science , operating system
The paper is divided into three sections. Section 1 consists of an account of the historical development of a biological concept for cancer control in mice by the senior author. Section 2 presents new data on the effect of a liver‐derived inhibitor of spontaneous tumors of mammary gland origin in mice in inducing a ‘transmissible entity’ that has been passed down through nine generations. The entity affects the biological characteristics of spontaneous tumors in mice and increases in potency in controlling cancer in mice of succeeding generations. The possibility of whether a genetic or a nongenetic transmission is involved in the passage of a ‘transmissible entity’ from generation to generation cannot be determined by the existing data. Section 3 lists the conclusions that have been reached concerning the biological and biochemical characteristics of the tumor inhibitor.