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Fluid therapy in hemorrhagic shock: Experimental evaluation
Author(s) -
Depalma Ralph G.,
Robinson Ann V.,
Holden William D.
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020406
Subject(s) - hypovolemia , medicine , hemorrhagic shock , shock (circulatory) , blood volume , osmotic concentration , saline , anesthesia , resuscitation
A model for the production of hemorrhagic shock in the rat was found to offer advantages over canine models. The ready availability of uniform inexpensive animals permitted evaluation of fluid therapy for hypovolemia. After 120 min of hypovolemia, reinfusion of the shed blood or infusion of Ringer's lactate or normal saline in a volume equal to three times the volume of the shed blood reduced mortality equally. The addition of 5% dextrose to Ringer's lactate produced a deleterious effect probably due to increased osmolarity.