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Renin and erythropoietin release in renal allotransplantation states
Author(s) -
Murphy G. P.,
Varkarakis M. J.,
Mirand E. A.
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020404
Subject(s) - medicine , azotemia , erythropoietin , hematocrit , allotransplantation , endocrinology , renal function , plasma renin activity , renin–angiotensin system , transplantation , urology , kidney , blood pressure
Erythropoietin (ESF) and renin assays were serially performed in untreated and azathioprine‐treated dog renal allografts. ESF levels accurately reflected the progressive decline in renal function, and degree of allograft rejection. ESF elevations did not correlate with the level of hematocrit, or degree of azotemia or hypertension. Renin levels, in contrast, were elevated to a variable and less marked degree and did not correlate with the level of hypertension, decline in renal function, degree of allograft rejection, or level of increased erythropoietin. ESF assays proved to be more accurate and reliable.