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The role of starvation, hypoglycemia, and adrenergic blockade on growth hormone secretion in obesity
Author(s) -
Herrold Joyce N.,
Tzagournis Manuel
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020311
Subject(s) - endocrinology , medicine , hypoglycemia , blockade , starvation , insulin , adrenergic , catecholamine , hormone , stimulus (psychology) , receptor , psychology , psychotherapist
The effects of starvation and refeeding on the circulating levels of human growth hormone (HGH) of seven obese subjects were studied with and without alpha and beta adrenergic blockade during an insulin tolerance test (ITT). The tests were performed during baseline, total fast, and refeeding periods. Autonomic blockade during starvation was not performed. The degrees of hypoglycemia produced during the mean baseline ITT before and after blockade and in the fasting period were comparable and associated with HGH levels of similar response. During refeeding, mean fasting glucose levels before and after blockade were higher than in control and fasting periods. The insulin‐induced hypoglycemia effect was comparable in percentage decrease, although absolute levels of hypoglycemia were less. There was correspondingly less response of HGH to this stimulus. This indicates that HGH secretion is normal in obesity provided sufficient hypoglycemia is produced a not apparently affected by circulating catecholamine levels.