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A case of myelocytic leukemia simulating the mouse model diseases
Author(s) -
Bennett Michael
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020308
Subject(s) - leukemia , medicine , myeloid leukemia , myeloid , cancer , immunology , cancer research , pathology
A case of myeloid leukemia is reported that occurred in a woman whose previous experiences are known to increase the incidence of myeloid leukemia in the mouse. Ovariectomy and sterile turpentine abscess formation increase the incidence of myeloid leukemia in mice exposed to ionizing radiation. In addition, antigenic similarities exist between certain variants of murine leukemia virus and mammary tumor virus. This patient experienced ovariectomy, thigh abscess formation, and partial body irradiation for carcinoma of the breast a few years before she developed leukemia. An association between human breast cancer and myelocytic leukemia has been described. While this case certainly does not prove that similar pathogenetic mechanisms of myeloid leukemia occur in mice and man, the events preceding the development of leukemia in this patient certainly mimicked the mouse models well.