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The direct effects of metolazone diuresis on the isolated bloodless perfused canine kidney
Author(s) -
Murphy G. P.,
Groenewald J. H.,
Kenny G. M.,
Reynoso G. F.
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020212
Subject(s) - diuretic , diuresis , medicine , urine flow rate , renal sodium reabsorption , reabsorption , renal function , urology , kidney , renal physiology , inulin , renal blood flow , pharmacology , endocrinology , chemistry , biochemistry
Renal bloodless perfusions under normothermic, normobaric conditions with oxygen or helium gas equilibrations were conducted in 14 canine kidneys. A new diuretic, metolazone (SR‐720—22), a quinazolinone compound, was evaulated for possible direct renal effects. Metolazone exerts direct renal effects with or without oxygen characterized by (1) fall in renal resistance; (2) rise in urine flow rate and osmolar clearance; (3) no change in GFR, in inulin extraction, or in the proximal tubular reabsorption of sodium. The agent at low doses is thus a potent and direct active diuretic. Lack of alteration in renal acidification processes as well as activity under anoxic conditions may indicate future usefulness in renal insufficiency states.