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Bone marrow colony‐stimulating factor: Renal influence on serum titers
Author(s) -
Foster Roger S.
Publication year - 1970
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930020102
Subject(s) - medicine , titer , bone marrow , nephrectomy , peripheral blood mononuclear cell , endocrinology , ligation , colony stimulating factor , bilateral nephrectomy , in vitro , kidney , immunology , antibody , stem cell , biology , haematopoiesis , biochemistry , genetics
The serum titer of colony‐stimulating factor which stimulates in vitro growth of bone marrow cells to form colonies of granulocytic and mononuclear cells is elevated 18 hr following bilateral ureteral ligation and unilateral or bilateral nephrectomy in mice. Following unilateral ureteral ligation, there is a moderate elevation of colony‐stimulating activity at 3 and 7 days. These results suggest that the titer of serum colony‐stimulating factor is dependent in part on renal clearance of the factor.