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Lack of effect of diphenylhydantoin ingestion on vesical transitional epithelium in the rat
Author(s) -
McDonald D. F.
Publication year - 1969
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930010109
Subject(s) - ingestion , medicine , urine , epithelium , carcinogen , endocrinology , pathology , biology , biochemistry
Seizure‐prone patients may be chronically treated with diphenylhydantoin, a mitogenic agent excreted in the urine. Chronic ingestion of diphenylhydantoin by 64 rats failed to demonstrate vesical epithelial tumor formation under conditions which demonstrate the tumorigenicity of other vesical carcinogens. Vesical neoplasms occurring in patients chronically ingesting diphenylhydantoin are probably co‐incidental.