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Phosphorylated mTOR expression as a predictor of survival after liver resection for colorectal liver metastases
Author(s) -
Konishi Takanori,
Yoshidome Hiroyuki,
Shida Takashi,
Furukawa Katsunori,
Takayashiki Tsukasa,
Kuboki Satoshi,
Takano Shigetsugu,
Miyazaki Masaru,
Ohtsuka Masayuki
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26551
Subject(s) - medicine , pi3k/akt/mtor pathway , colorectal cancer , immunohistochemistry , hepatectomy , oncology , gastroenterology , cancer , cancer research , pathology , resection , surgery , apoptosis , biology , biochemistry
Background Phosphorylated mammalian target of rapamycin (p‐mTOR) plays a crucial role in the process of cancer progression. Common gene mutations of colorectal cancer lead to the activation of the PI3k/Akt/mTOR pathway. In this study, we determined whether p‐mTOR expression in colorectal liver metastases is a predictive marker of prognosis following liver resection. Methods Eighty‐one patients with colorectal liver metastases who had undergone curative resection were evaluated using immunohistochemistry of p‐mTOR. Data regarding clinicopathological features and patient survival were analyzed. Results The p‐mTOR expression in colorectal liver metastases was detected in 55 (67.9%) patients. Patients whose metastases had high p‐mTOR expression showed a significantly lower overall survival rate after resection as compared to patients with low p‐mTOR expression ( p = 0.016), while there was no significant difference in the disease‐free survival between the two groups. Repeat resection for recurrence was performed more frequently in patients with p‐mTOR positive than others ( p = 0.024). Multivariate analysis showed that p‐mTOR expression was an independent prognostic factor of overall survival after liver resection ( p = 0.019). Conclusions mTOR was frequently activated in colorectal liver metastases, and the p‐mTOR expression was a biological marker for predicting the overall survival of patients with colorectal liver metastases following liver resection.