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Initial clinical experiences using the intraoperative probe‐based parathyroid autofluorescence identification system—PTeye™ during thyroid and parathyroid procedures
Author(s) -
Kiernan Colleen M.,
Thomas Giju,
Baregamian Naira,
Solόrzano Carmen C.
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26500
Subject(s) - medicine , autofluorescence , thyroid , clearance , predictive value , parathyroid gland , confidence interval , prospective cohort study , surgery , urology , parathyroid hormone , calcium , physics , quantum mechanics , fluorescence
Background and Objective The Food and Drug Administration has cleared a probe‐based near‐infrared autofluorescence (NIRAF) detection system called PTeye™ as an adjunct tool for label‐free intraoperative parathyroid gland (PG) identification. Since PTeye™ has been investigated only in a “blinded” manner to date, this study describes the preliminary impressions of PTeye™ when used by surgeons without being blinded to the device output. Methods Patients undergoing thyroid and parathyroid procedures were prospectively recruited. Target tissues were intraoperatively assessed with PTeye™. The surgeon's confidence in PG identification was recorded concomitantly with NIRAF parameters that were output in real‐time from PTeye™. Results A retrospective review of prospectively collected data on 83 patients was performed. PTeye™ was used for interrogating 336 target tissues in 46 parathyroid and 37 thyroid procedures. PTeye™ yielded an overall accuracy of 94.3% with a positive predictive value of 93.0% and a negative predictive value of 100%. An increase in confidence for intraoperative PG identification with PTeye™ was observed by all three participating high‐volume surgeons, irrespective of their level of accrued surgical experience. Conclusions Probe‐based NIRAF detection with PTeye™ can be a valuable adjunct device to intraoperatively identify PGs for surgeons of varied training and experience.