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The role of 18 F‐FDG PET/CT in retroperitoneal sarcomas—A multicenter retrospective study
Author(s) -
Subramaniam Suren,
Callahan Jason,
Bressel Mathias,
Hofman Michael S.,
Mitchell Catherine,
Hendry Shona,
Vissers Frederique L.,
Van der Hiel Bernies,
Patel Dakshesh,
Van Houdt Winan J.,
Tseng William W.,
Gyorki David E.
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26379
Subject(s) - medicine , leiomyosarcoma , standardized uptake value , positron emission tomography , nuclear medicine , pathological , radiology , liposarcoma , retrospective cohort study , sarcoma , pathology
Background The role of 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F‐FDG PET/CT) in the evaluation of retroperitoneal sarcomas is poorly defined. We evaluated the correlation of maximum standardized uptake value (SUVmax) with pathologic tumor grade in the surgical specimen of primary retroperitoneal dedifferentiated liposarcoma (DDLPS) and leiomyosarcoma (LMS). Methods Patients with the above histological subtypes in three participating institutions with preoperative 18 F‐FDG PET/CT scan and histopathological specimen available for review were included. The association between SUVmax and pathological grade was assessed. Correlation between SUVmax and relapse‐free survival (RFS) and overall survival (OS) were also studied. Results Of the total 58 patients, final pathological subtype was DDLPS in 44 (75.9%) patients and LMS in 14 (24.1%) patients. The mean SUVmax was 8.7 with a median 7.1 (range, 2.2–33.9). The tumors were graded I, II, III in 6 (10.3%), 35 (60.3%), and 17 (29.3%) patients, respectively. There was an association of higher histological grade with higher SUVmax ( r s = 0.40, p = .002). Increasing SUVmax was associated with worse RFS ( p = .003) and OS ( p = .003). Conclusion There is a correlation between SUVmax and pathologic tumor grade; increasing SUVmax was associated with worse OS and RFS, providing a preoperative noninvasive surrogate marker of tumor grade and biological behavior.