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Primary mesenteric sarcomas: Collaborative experience from the Trans‐Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)
Author(s) -
Tattersall Hannah L.,
Hodson James,
Cardona Kenneth,
Lee Rachel M.,
Nessim Carolyn,
Gladdy Rebecca,
Van Der Hage Jos,
Schrage Yvonne,
Tseng William W.,
Houdt Winan,
Novak Marko,
Grignani Giovanni,
Tolomeo Francesco,
Goel Neha,
Ryon Emily,
Gyorki David,
Bagaria Sanjay P.,
Gonzalez Jose A.,
Arnau Ana B. M.,
Sayyed Raza,
Tirotta Fabio,
Evenden Caroline,
Desai Anant,
Almond Max,
Glasbey James,
Fiore Marco,
Gronchi Alessandro,
Ford Samuel J.
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26353
Subject(s) - medicine , sarcoma , mesentery , soft tissue sarcoma , surgical oncology , resection , survival rate , primary tumor , surgery , radiology , metastasis , pathology , cancer
Background Primary mesenteric soft tissue sarcomas (STS) are rare and limited evidence is available to inform management. Surgical resection is challenging due to the proximity of vital structures and a need to preserve enteric function. Objectives To determine the overall survival (OS) and recurrence‐free survival (RFS) for patients undergoing primary resection for mesenteric STS. Methods The Trans‐Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) is an intercontinental collaborative comprising specialist sarcoma centers. Data were collected retrospectively for all patients with mesenteric STS undergoing primary resection between 2000 and 2019. Results Fifty‐six cases from 15 institutions were included. The spectrum of pathology was similar to the retroperitoneum, although of a higher grade. R0/R1 resection was achieved in 87%. Median OS was 56 months. OS was significantly shorter in higher‐grade tumors ( p = .018) and extensive resection ( p < .001). No significant association between OS and resection margin or tumor size was detected. Rates of local recurrence (LR) and distant metastases (DM) at 5 years were 60% and 41%, respectively. Liver metastases were common (60%), reflecting portal drainage of the mesentery. Conclusion Primary mesenteric sarcoma is rare, with a modest survival rate. LR and DM are frequent events. Liver metastases are common, highlighting the need for surveillance imaging.