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A clinicopathologic examination of myxofibrosarcoma. Do surgical margins significantly affect local recurrence rates in this infiltrative sarcoma subtype?
Author(s) -
Dadrass Farnaz,
Gusho Charles,
Yang Fan,
Culvern Chris,
Bloom Julie,
Fillingham Yale,
Colman Matthew,
Gitelis Steven,
Blank Alan
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26277
Subject(s) - myxofibrosarcoma , medicine , sarcoma , soft tissue sarcoma , soft tissue , retrospective cohort study , demographics , surgical margin , distant metastasis , metastasis , surgery , disease , radiology , pathology , cancer , resection , sociology , demography
Background and Objectives Myxofibrosarcoma (MFS) is an aggressive soft tissue tumor with an unpredictable recurrence pattern. We sought to (a) determine whether margin status in MFS is correlated to rates of local recurrence (LR) and (b) identify demographic and treatment variables associated with disease‐related outcomes in this population. Methods This retrospective study identified 42 surgically treated patients with MFS over 10 years at a single institution. Patient demographics, tumor characteristics, intraoperative variables, and disease‐related outcomes were recorded. Results Thirty‐three (83%) patients had negative surgical margins and seven (18%) had positive margins. Four of 32 patients (13%) with negative margins developed subsequent LR compared to six of seven (86%) patients with positive margins ( p < .001). Three patients (75%) with metastatic disease were deceased at the end of the study, while five (15%) without metastasis were deceased ( p = .024). Conclusions Positive margin procedures for MFS were associated with LR. However, negative surgical margins demonstrated a relatively high rate of LR compared to other soft tissue sarcoma subtypes. Furthermore, though MFS tends to locally recur and have a propensity for distant metastasis, patients are observed to have a higher probability of death from other causes.