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Clinicopathological and prognostic analyses of 86 resected pulmonary lymphoepithelioma‐like carcinomas
Author(s) -
Chen Jiafei,
Gu Chang,
Chen Xiaojian,
Dai Chenyang,
Zhao Shengnan,
Xie Huikang,
Fei Ke,
Chen Chang
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26276
Subject(s) - medicine , lymphoepithelioma like carcinoma , lung cancer , immunohistochemistry , stage (stratigraphy) , pathology , carcinoma , lung , oncology , gastroenterology , immunology , epstein–barr virus , paleontology , virus , biology
Abstract Background Pulmonary lymphoepithelioma‐like carcinoma (LELC) is a rare subtype of primary lung cancer. The present study aims at investigating clinicopathological features and prognostic characteristics of the resected pulmonary LELC. Methods Patients with resected pulmonary LELC were identified in our hospital from December 2008 to December 2018. Data of these patients were retrospectively reviewed, clinicopathological features and prognostic characteristics were analyzed subsequently. Results In total, 86 patients were enrolled in the study, including 39 (45.3%) males and 47 (54.7%) females. Most of the serum tumor markers were normal. Immunohistochemical staining result showed frequent differentiation traits of epithelial tissue such. Positive PD‐L1 (15 of 19, 78.9%) and PD‐1 (13 of 17, 76.5%) were also common, but cancer‐related genetic mutation was scarce (1 of 47, 2.1%). Survival analyses demonstrated that the N stage ( p = .011) and extent of resection ( p = .023) were identified as independent predictive factors for overall survival. Conclusions Pulmonary LELC is a distinctive subtype of lung cancer with several exclusive traits, such as the trend to happen among nonsmoking young people, epithelial origin of tumor differentiation, frequent expression of the immune checkpoint, and scarce presence of driver mutation. In addition, pulmonary LELC was apt to get a favorable outcome, especially in cases diagnosed and treated in the early stage.