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Health‐related quality of life and treatment modality among esophageal squamous cell carcinoma survivors: A prospective study using time to deterioration model analysis
Author(s) -
Liu Shuang,
Lin Zheng,
Lin Jianbo,
Chen Huilin,
Xie Qianwen,
Rao Wenqing,
Chen Yuanmei,
Yu Kaili,
Hu Zhijian
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26264
Subject(s) - medicine , quality of life (healthcare) , swallowing , dysphagia , choking , chemotherapy , prospective cohort study , surgery , nursing , anatomy
Background and Objectives This study aimed to analyze the association between health‐related quality of life and treatment modality among esophageal squamous cell carcinoma (ESCC) survivors. Methods Patients completed the EORTC QLQ‐C30 and EORTC QLQ‐OES18 at baseline and follow‐up. A time to deterioration model analysis was performed to compare longitudinal EORTC QLQ‐C30/QLQ‐OES18 data between surgery alone and surgery with adjuvant chemotherapy. Results For EORTC QLQ‐C30 scale, compared with surgery alone, significant delays in time to deterioration in role functioning (16.05 months vs. 15.00 months; p = .045), cognitive functioning (20.80 months vs. 16.26 months; p = .017), social functioning (19.09 months vs. 12.35 months; p = .001), and dyspnea (18.53 months vs. 14.62 months; p = .011) were observed for surgery with adjuvant chemotherapy. For QLQ‐OES18 scale, compared with surgery alone, significant delays in time to deterioration in dysphagia (13.75 months vs. 8.16 months; p = .005), choking when swallowing (20.67 months vs. 15.08 months; p = .001), and dry mouth (21.78 months vs. 17.28 months; p = .039) were observed for surgery with adjuvant chemotherapy. Conclusions Patients who received postoperative chemotherapy had significant delay in time to deterioration in multiple ESCC‐related symptoms, functions of EORTC QLQ‐C30 and EORTC QLQ‐OES18.