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Active surveillance or early resection for ground‐glass nodules that need preoperative localization
Author(s) -
Tsai PingChung,
Hsu PoKuei,
Yeh YiChen,
Chen ChunKu,
Chang YingYueh,
Huang ChienSheng,
Hsu HanShui
Publication year - 2021
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26241
Subject(s) - medicine , pathological , malignancy , resection , carcinoma , lung cancer , lung cancer screening , lung , radiology , surgery
Few studies have investigated the impact of active surveillance on pathological outcome ground‐glass nodules (GGNs). We focused on GGNs that needed preoperative localization before resection and compared the pathological results between GGNs that underwent early resection or active surveillance. Methods We retrospectively reviewed data of resected GGNs between January 2017 and December 2018. GGNs were classified by early resection (Group A) and active surveillance (Group B). Group B was subclassified as no (Group B1) and with (Group B2) growth, and intergroup comparison of pathological results was undertaken. Results In total, 509 GGNs (124, 275, and 110 in Groups A, B1, and B2, respectively) were included. Malignancy (primary lung cancer) ratios were 68% and 72% in Groups A and B ( p = .312) and 65% and 92% in Groups B1 and B2, respectively ( p < .001). The ratios of invasive carcinoma were 21.4%, 9.6%, and 35.6% in Groups A, B1, and B2, respectively. Predictors for invasive carcinoma included history of lung cancer, GGN size ≥ 10 mm, solid size ≥ 6 mm, and GGN growth. Conclusions The pathological findings were similar for GGNs in the early resection and active surveillance groups. However, rates of malignancy and invasive carcinoma increased in the group that manifested growth during active surveillance.