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Impact of body mass index on postoperative outcomes in patients undergoing radical resection for hilar cholangiocarcinoma
Author(s) -
Zhou Tian,
Liu Li,
Dai HaiSu,
Zhang ChengCheng,
He Yu,
Zhang LeiDa,
Li DaJiang,
Bie Ping,
Ding Jun,
Chen ZhiYu
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.26172
Subject(s) - medicine , body mass index , logistic regression , risk factor , surgery , gastroenterology , mass index
Abstract Background Body mass index (BMI) has been widely used as a prognostic indicator. The association between preoperative BMI and postoperative morbidity in patients with hilar cholangiocarcinoma (HCCA) has not been proved. This study aimed to identify the association between preoperative BMI and postoperative morbidity following radical resection of HCCA. Methods Patients were divided into three groups according to preoperative BMI: low BMI (≤18.4 kg/m 2 ), normal BMI (18.4‐24.9 kg/m 2 ), and high BMI (≥24.9 kg/m 2 ). Baseline characteristics, operative variables, postoperative 30‐day mortality, and morbidity were compared. Risk factors associated with postoperative morbidity were assessed using univariable and multivariable logistic analyses. Results Among 260 patients, 183 (70.4%) had normal BMI, 32 (12.3%) had low BMI, and 45 (17.3%) had high BMI. Compared to the patients with normal‐BMI, both low and high BMI patients exhibited a significantly higher postoperative morbidity (87.5% and 82.2% vs 63.9%, P = .019 and P = .025, respectively). Additionally, the multivariable analysis revealed that both low and high BMI patients remained independently associated with an increased risk of postoperative morbidity. (OR: 3.707, 95% CI: 1.080‐12.725, P = .037; and OR: 2.858, 95% CI: 1.167‐7.002, P = .022, respectively). Conclusion BMI is an independent risk factor for higher postoperative morbidity in patients who undergo surgical treatment of hilar cholangiocarcinoma.