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Metastatic patterns do not provide additional prognostic information for patients with FIGO stage IV high‐grade serous ovarian cancer
Author(s) -
Feng Zheng,
Wen Hao,
Ju Xingzhu,
Bi Rui,
Chen Xiaojun,
Yang Wentao,
Wu Xiaohua
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25941
Subject(s) - medicine , stage (stratigraphy) , serous fluid , ovarian cancer , serous ovarian cancer , oncology , cancer , gynecology , paleontology , biology
Background The aim of our study was to investigate whether metastatic patterns were associated with the prognosis of patients with FIGO stage IV high‐grade serous ovarian cancer (HGSC). Methods We retrospectively investigated 83 consecutive patients with FIGO stage IV HGSC who underwent primary surgery between April 2005 and June 2013 at our institution. Metastatic patterns were defined as pleural effusion (stage IVA), parenchymal metastases (stage IVB), and extra‐abdominal lymph node metastases (stage IVB). Correlations of clinical characteristics and prognosis with metastatic patterns were analyzed. Results Forty‐two (50.6%) patients were stage IVA with pleural effusion. Among the remaining stage IVB patients, 19 (22.9%) patients had parenchymal metastases and 22 (26.5%) had extra‐abdominal lymph node metastases. FIGO IVA and IVB subclassification did not have a prognostic impact on progression‐free survival (PFS) ( P = .361). In addition, no differences in PFS were observed among patients presenting the three metastatic patterns ( P = .506). The 5‐year overall survival (OS) rates of patients with stage IVA and IVB diseases were 35.2% and 34.3%, respectively, ( P = .856). In addition, metastatic patterns did not provide additional prognostic information for OS ( P = .292). Conclusion Neither the subclassification into FIGO IVA and IVB stages nor metastatic patterns of FIGO stage IV provided additional prognostic information.