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The impact of wait times on oncological outcome in high‐risk patients with endometrial cancer
Author(s) -
Mitric Cristina,
Matanes Emad,
Wissing Michel,
Amajoud Zainab,
Abitbol Jeremie,
Yasmeen Amber,
LópezOzuna Vanessa,
Eisenberg Neta,
Laskov Ido,
Lau Susie,
Salvador Shan,
Gotlieb Walter H.,
Kogan Liron
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25929
Subject(s) - medicine , endometrial cancer , hazard ratio , lymphovascular invasion , confidence interval , proportional hazards model , stage (stratigraphy) , cancer , biopsy , surgery , endometrial biopsy , survival analysis , urology , oncology , gynecology , metastasis , paleontology , biology
Objective To evaluate the impact of surgical wait times on outcome of patients with grade 3 endometrial cancer. Methods All consecutive patients surgically treated for grade 3 endometrial cancer between 2007 and 2015 were included. Patients were divided into two groups based on the time interval between endometrial biopsy and surgery: wait time from biopsy to surgery ≤12 weeks (84 days) vs more than 12 weeks. Survival analyses were conducted using log‐rank tests and Cox proportional hazards models. Results A total of 136 patients with grade 3 endometrial cancer were followed for a median of 5.6 years. Fifty‐one women (37.5%) waited more than 12 weeks for surgery. Prolonged surgical wait times were not associated with advanced stage at surgery, positive lymph nodes, increased lymphovascular space invasion, and tumor size ( P = .8, P = 1.0, P = .2, P = .9, respectively). In multivariable analysis adjusted for clinical and pathological factors, wait times did not significantly affect disease‐specific survival (adjusted hazard ratio [HR]: 1.2, 95% confidence interval [CI], 0.6‐2.5, P = .6), overall survival (HR: 1.1, 95% CI, 0.6‐2.1, P = .7), or progression‐free survival (HR: 0.9, 95% CI, 0.5‐1.7, P = .8). Conclusion Prolonged surgical wait time for poorly differentiated endometrial cancer seemed to have a limited impact on clinical outcomes compared to biological factors.