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Sarcopenia is associated with increased mortality but not complications following resection and reconstruction of sarcoma of the extremities
Author(s) -
Hendrickson Nathan R.,
Mayo Zachary,
Shamrock Alan,
Kesler Kyle,
Glass Natalie,
Nau Peter,
Miller Benjamin J.
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25898
Subject(s) - medicine , sarcopenia , hazard ratio , sarcoma , surgery , odds ratio , body mass index , proportional hazards model , retrospective cohort study , confidence interval , pathology
Background and Objectives Evidence regarding the impact of sarcopenia on operative outcomes in patients with sarcoma is lacking. We evaluated the relationship between sarcopenia and postoperative complications or mortality among patients undergoing tumor excision and reconstruction. Methods We retrospectively reviewed 145 patients treated with tumor excision and limb reconstruction for sarcoma of the extremities. Sarcopenia was defined as psoas index (PI) < 5.45 cm 2 /m 2 for men and <3.85 cm 2 /m 2 for women from preoperative axial CT. Regression analyses were used to assess the association between postoperative complications or mortality with PI, age, gender, race, body mass index, tumor histology, grade, depth, location, size, and neoadjuvant/adjuvant therapy. Results There were 101 soft tissue tumors and 44 primary bone tumors. Sarcopenia was present in 38 patients (26%). Sarcopenic patients were older (median age: 72 vs 59 years, P = .0010) and had larger tumors (86.5%, >5 cm vs 77.7%, P = .023). Seventy‐three patients experienced complications (51%) and 18 patients died within 1 year. Sarcopenia and metastatic disease were associated with increased 12‐month mortality (hazard ratio [HR] = 6.68, P < .001; HR: 8.51, P < .001, respectively) but not complications (HR 1.45, P = .155, odds ratio, 1.32, P = .426, respectively). Conclusions Sarcopenia and metastatic disease were independently associated with postoperative mortality but no complications following surgery.