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Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers
Author(s) -
Wecsler Julie,
Jeong Young Ju,
Raghavendra Akshara S.,
Mack Wendy J.,
Tripathy Debasish,
Yamashita Mary W.,
Sheth Pulin A.,
Hovanessian Larsen Linda,
Russell Christy A.,
MacDonald Heather,
Sener Stephen F.,
Lang Julie E.
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25855
Subject(s) - medicine , occult , breast mri , magnetic resonance imaging , breast cancer , radiology , biopsy , mammography , invasive lobular carcinoma , cancer , pathology , invasive ductal carcinoma , alternative medicine
Background The use of preoperative magnetic resonance imaging (MRI) for newly diagnosed breast cancer remains controversial. We examined factors associated with detection of occult multicentric, multifocal, and contralateral malignant lesions only seen by MRI. Methods We performed a retrospective analysis of consecutive patients undergoing preoperative MRI for breast cancer. Clinicopathologic data were assessed regarding the findings of multifocality, multicentricity, and the presence of contralateral lesions. We analyzed the association of factors with these findings on MRI. Results Of 857 patients undergoing MRI, 770 patients met inclusion criteria. Mean age was 54.7 years. Biopsy‐proven detection rates by MRI for multifocal, multicentric, and contralateral cancers were 6.2% (48 of 770), 1.9% (15 of 770) and 3.1% (24 of 770), respectively. African American race and heterogeneously or extremely dense mammographic density were associated with multifocal cancers on MRI. Larger lesion size and mammographic density were associated with multicentric cancers. Invasive lobular carcinoma (ILC) and progesterone receptor (PR)‐positivity were associated with contralateral cancers. Conclusions African American race, heterogeneously or extremely dense mammographic density, ILC, and PR‐positivity were associated with additional biopsy‐proven cancers based on MRI. These factors should be considered when assessing the clinical utility of preoperative breast MRI.