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Late locoregional complications associated with adjuvant radiotherapy in the treatment of breast cancer: Systematic review and meta‐analysis
Author(s) -
Kanda Márcia Helena,
Costa Vieira René Aloisio,
Lima João Paulo S. N.,
Paiva Carlos Eduardo,
Araujo Raphael Leonardo Cunha
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25820
Subject(s) - medicine , meta analysis , radiation therapy , lymphedema , adjuvant radiotherapy , breast cancer , capsular contracture , mastectomy , adjuvant , surgery , cancer , oncology , breast reconstruction
This systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associated with an increased risk of capsular contracture and decreased the mobility of the upper limb. A borderline association of lymphedema risk using RT was noted in the random‐effects model but was significant in the fixed‐effects model.