Premium
Clinical features of sarcomatoid change in patients with intrahepatic cholangiocarcinoma and prognosis after surgical liver resection: A Propensity Score Matching analysis
Author(s) -
Wang Tao,
Kong Junjie,
Yang Xianwei,
Shen Shu,
Zhang Menglan,
Wang Wentao
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25815
Subject(s) - medicine , propensity score matching , intrahepatic cholangiocarcinoma , resection , surgery , surgical resection , hepatectomy , oncology , general surgery , radiology
Background Intrahepatic cholangiocarcinoma with sarcomatoid change (iCCA‐SC) is a rare histological subtype of iCCA, the clinical features and outcomes after surgical resection on the prognosis is still unknown. Methods We retrospectively reviewed the clinical data of patients with histologically proven iCCA who underwent curative liver resection at our hospital between January 2008 and December 2018. Propensity score matching analysis was used to match patients with and without sarcomatoid change at a ratio of 1:4. The nomogram integrating all significant independent factors for overall survival (OS) and recurrence‐free survival (RFS) was constructed to predict prognosis for iCCA. The predictive accuracy ability of the nomogram was determined by Harrell's index (C‐index). Results A total of 40 iCCA‐SC and 160 ordinary iCCA patients were included in this study. RFS and OS in the iCCA‐SC group were significantly lower than those in the ordinary iCCA group ( P <.001 and P = .002, respectively). The calibration curve for the probability of survival showed good agreement between the nomogram prediction and actual observation. Conclusion The histological sarcomatoid subtype is an independent predictor of tumor recurrence and shorter OS in iCCA patients. The nomogram we established could provide more accurate prognostic prediction for iCCA patients.