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Disappearing colorectal liver metastases: Strategies for the management of patients achieving a radiographic complete response after systemic chemotherapy
Author(s) -
Araujo Raphael L. C.,
Milani Jean Michel,
Armentano Daniela Pezzutti,
Moreira Raphael Brandão,
Pinto Gustavo S. F.,
Castro Luís Antônio,
Lucchesi Fabiano R.
Publication year - 2020
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25784
Subject(s) - medicine , chemotherapy , context (archaeology) , liver parenchyma , colorectal cancer , radiography , radiology , systemic therapy , parenchyma , oncology , surgery , pathology , cancer , paleontology , biology , breast cancer
The mainstays of treatment for colorectal liver metastases (CRLMs) are surgery and chemotherapy. Chemotherapeutic benefits of tumor shrinkage and systemic control of micrometastases are in part counterbalanced by chemotoxicity that can modify the liver parenchyma, jeopardizing the detection of CRLM. This review addresses the clinical decision‐making process in the context of radiographic and pathologic responses, the preoperative imaging workup, and the approaches to the liver for CRLM, which disappear after systemic chemotherapy.